Ingenious Multifunctional MnO2 Quantum Dot Nanozymes with Superior Catechol Oxidase-like Activity for Highly Selective Sensing of Redox-Active Dopamine Based on an Interfacial Passivation Strategy. Wenting Zou, Yan Liu, Renjie Li, Rong Guo.Injectable Antibacterial Gelatin-Based Hydrogel Incorporated with Two-Dimensional Nanosheets for Multimodal Healing of Bacteria-Infected Wounds. Shayesteh Bochani, Ali Kalantari-Hesari, Fakhri Haghi, Vajihe Alinezhad, Hadi Bagheri, Pooyan Makvandi, Mohammad-Ali Shahbazi, Abdollah Salimi, Ikue Hirata, Virgilio Mattoli, Aziz Maleki, Baolin Guo.Is Graphene Shortening the Path toward Spinal Cord Regeneration?. Girão, María Concepcion Serrano, António Completo, Paula A. Amorphizing Metal Selenides-Based ROS Biocatalysts at Surface Nanolayer toward Ultrafast Inflammatory Diabetic Wound Healing. Rodriguez, Wei Geng, Qiu Chen, Chong Cheng, Changsheng Zhao. Yuting Deng, Yang Gao, Tiantian Li, Sutong Xiao, Mohsen Adeli, Raul D.
This article is cited by 93 publications. Therefore, the MnO 2 NP-dotted hydrogel represents a promising strategy for stem-cell-based therapies of central nervous system diseases through the comprehensive regulation of pathological microenvironment complications. Transplantation of MSCs in the multifunctional gel generates a significant motor function restoration on a long-span rat spinal cord transection model and induces an in vivo integration as well as neural differentiation of the implanted MSCs, leading to a highly efficient regeneration of central nervous spinal cord tissue.
The MnO 2 NPs alleviate the oxidative environment, thereby effectively improving the viability of MSCs. The peptide-modified hydrogel enables the adhesive growth of mesenchymal stem cells (MSCs) and nerve tissue bridging. Herein, a MnO 2 nanoparticle (NP)-dotted hydrogel is prepared through dispersion of MnO 2 NPs in a PPFLMLLKGSTR peptide modified hyaluronic acid hydrogel. However, stem cell treatment of SCI has been severely impaired by the increased generation of reactive oxygen species in the lesion microenvironment, which can lead to a high level of stem cell death and dysfunction. Spinal cord injury (SCI) is one of the most debilitating injuries, and transplantation of stem cells in a scaffold is a promising strategy for treatment.
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